So, playing devil's advocate:
Going N/A you're going to have to rev the hell outof it anyway. Why not go with a 2.5 block and a forged 2.0 crank (fairly cheap from a miata engine)?
I believe you would need custom rods, but this is one of the lightest cranks available, it would decrease piston velocity, the larger bore would optimize the dispersal of the intake charge, shorter stroke would improve vibration of rotating assembly and promote longer life at high rpms, and you would still end up somewhere between a 2.1 and 2.2 (I didn't do the math, correct me if I am wrong).
If the engine is larger, you aren't going to have to rev the hell out of it. Even though the specific output of the smaller engine can be better, it won't be that much better. All else being equal, if I were shooting for 220 fwhp, I'd rather have it from a 2.5 than a 2.0. The piston speed is probably going to be the same maybe a slight advantage to a 2.0 particularly if you optimize the bore/stroke like you are talking about, but the bearing speeds will be slower, the valve spring loads lower, so the oil and coolant heating will be much less, which to me is the key. Nearly everything sees less stress because the engine is turning less RPM and making less heat.
This is, in part, why 8 liter Vipers and 7 liter Corvettes did so well in endurance racing. The air inlet restrictor meant everyone would make the same HP, so why not get a big honking engine that can make that same horsepower with lower stress? Since I am looking for a track day car engine (24 minute sessions not 24 hours but way lower budget) I am apt to apply the same thinking. Go big for lower stress at the same power level.
Now, I could be wrong, but that is where I stand right now. I certainly enjoy hearing other opinions and thought processes.